• Is a negative acute phase protein.
• If  a reference value of 35 to 45 g / l.
• Responsible for 80% of the colloid osmotic pressure and comprises 50-60% of the total plasma protein.
• Is a transport protein for fatty acids, bilirubin and some hormones.
• Is synthesized in the liver, approximately 200 mg / kg / day, which is less than 5% of the total body stores. The synthesis capacity of the liver can increase 2-3 times. The body stock includes approximately 3.5-5.0 g / kg body weight and 35-40% of this is intravascular.
• Has a half life of 20 days.
• In an albumin of 34 g / l or less is an inflammatory response in the body (often with a rapid increase in CRP).

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In the 19th century the interest in the ‘aqueous fraction “of blood rapidly. This fraction was a source for the isolation of new components. In 1888 the German scientist Hofmeister published on the behavior and the solubility of blood proteins. Using ammonium sulphate did he distinguish between groups that he “albumin” and “globulins” called. His so-called principle of “differential precipitation” as separation technique is still used. During the Second World War in Boston the physical chemist Edwin Cohn a process to separate plasma into separate groups. Plasma proteins such as albumin could be obtained in concentrated form. While several researchers later adjustments in process conditions are introduced, they work in many places even as described by cohn. After the war, the development was rapid. In 1964 the U.S. Judith Pool discovered by chance that when slowly thawing frozen plasma at a temperature just above freezing, there is a precipitate forms which enhanced coagulation factor VIII is present. The discovery of this so-called Cryoprecipitate as a method for obtaining factor VIII was a breakthrough for the treatment of patients with blood clotting disease Haemophilia A. Meanwhile, a large number of important plasma proteins are isolated and used as medicine (see figure below).

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Almost 7 000 patients participated in the study, the risk of death for patients who received albumin was the same as that of patients who received saline (relative risk 0.99, confidence interval 95 % 0.91 to 1.09), which is answer questions about the safety of albumin raised in 1998. However, the study did not include severe burns, and exploratory analysis of the subgroup of trauma victims revealed that the mortality rate associated with the use of albumin was higher in patients who had a concomitant brain injury (relative risk 1.36, confidence interval 95% 0.99 to 1.86, p = 0.04). There was better survival in patients with sepsis who received albumin, but this observation was not significant statistically (relative risk 0.87, confidence interval 95% 0.74 to 1 , 02, p = 0.09), and its importance clinically is unclear. It should be noted that the study was not powered to show differences between subgroups and that such differences may be due to chance.
A new meta-analysis of various studies, including the SAFE study, conducted by the Cochrane Injuries Group3 and published October 18, 2004, the relative risk of death associated with the use of albumin in Hypovolemic patients would be 1, 01 (confidence interval 95% 0.92 to 1.10), so the use of albumin does not increase nor decrease mortality rate in these patients.
To determine whether the use of albumin has certain advantages or risks in certain subgroups of patients, we must conduct studies that focus specifically on this issue and have the necessary power.
The identification, characterization and management of adverse events related to a marketed health product depend on the active participation of health professionals program for reporting adverse reactions.

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